Alzheimer’s Diet -How to Prevent and Reverse Cognitive Decline

The-Alzheimer-Diet-How-To-Reduce-And-Prevent-Cognitive-Decline-by-Amos-Institute-byThe-World-of-Health-

The Alzheimer’s Diet: How to Prevent and Reverse Cognitive Decline by Amylee Amos

 

Worldwide, about 50 million people are suffering from dementia. Alzheimer’s disease is the most common form of dementia and the emotional and financial toll of this disease is monumental. Alzheimer’s disease is now considered to be the 3rd leading cause of death with no pharmaceutical drugs available to effectively treat the disease, though not for lack of trying on the part of the pharmaceutical industry.

Alzheimer’s drug development has the highest failure rate of any other disease, at 99.6%. That equates to billions of dollars thrown into potential treatments that do shockingly little to slow the progress, reverse the symptoms, or even prevent the disease. The five drugs that have been approved for Alzheimer’s treatment do very little to help the millions of people suffering from the cognitive losses and devastation associated with Alzheimer’s.   

Fortunately, recent research demonstrates that Alzheimer’s is not the idiopathic disease it was once believed to be. In fact, the causes and contributors of an individual’s Alzheimer’s disease can be pinpointed and treated.

Contributors to the programmatic downsizing of the brain that is Alzheimer’s disease include physiological processes such as chronic inflammation, imbalanced oxidative stress, and impaired glycemic control.

These factors are all highly influenced by our diet. Thus, adopting an Alzheimer’s diet is critical in the attempt to prevent and reverse cognitive decline. 

Can Alzheimer’s Disease Be Prevented and Reversed?

 

The mainstream medical community is always quick to comment that there is no cure for Alzheimer’s disease. This just means that no silver bullet approach to preventing or reversing Alzheimer’s exists. You can’t just pop a pill and reverse your Alzheimer’s disease. Thus, because their outdated approach to treating chronic diseases fails in the case of Alzheimer’s, the conventional medicine community remains steadfast in their misguided claim that there is no effective treatment for Alzheimer’s disease. 

The truth is that through a targeted therapeutic approach, Alzheimer’s disease can be prevented and the symptoms can be reversed. In 2018, practitioners from multiple clinical sites published the reversal of cognitive decline in 100 patients while following a multi-targeted approach.

This approach, which adheres to the functional medicine model of addressing the underlying root causes of disease is known as the Bredesen Protocol. Through the Bredesen Protocol practitioners are able to identify the individual metabolic imbalances of each patient and use a systems based approach to treat each imbalance, thereby identifying and treating the root cause of the imbalance, rather than simply masking the symptoms. The result is the reversal of cognitive decline. 

What Is The Alzheimer’s Diet?

Alzheimer's Diet Dr Bredesen Protocol To Reverse Cognitive Decline In Alzheimers

The ideal Alzheimer’s diet to prevent and reverse cognitive decline must be individualized to the patient to ensure that it addresses the root cause of that person’s metabolic imbalances.

However, there are some nutritional components that all those wishing to prevent cognitive decline should adopt. Adjusting one’s nutritional habits to reflect the Alzheimer’s diet is the first step in preventing cognitive decline. 

The foundation of the Alzheimer’s diet is whole, predominantly plant-based foods including non-starchy vegetables, low glycemic fruits, quality proteins, and healthy fats.

Clients following the Alzheimer’s diet are encouraged to eat foods that have been well-studied for their cognitive benefits including leafy greens, cruciferous vegetables, berries, low mercury fatty fish, extra virgin olive oil, and walnuts.

Eliminating Processed Fats and Refined Carbohydrates

 

The diet eliminates highly processed packaged foods, simple and added sugars, processed meats, and refined carbohydrates.

Animal products in general are minimized depending on the specifics of an individual’s drivers of inflammation.

Consuming adequate amounts of the recommended foods provides the nutrients, specifically the micro and phytonutrients that the brain needs to support neuronal and synaptic growth and function. Avoiding the foods not recommended prevents ongoing inflammation and resolves oxidative stress and cellular dysfunction.

Fasting On The Alzheimer’s Diet

Additionally, clients following the Alzheimer’s diet are encouraged to fast for a period of at least 12 hours overnight, with the first three hours occurring between finishing dinner and going to bed. This fast allows for the client to reap the full physiological benefits of sleep, including the natural clearance of beta-amyloid plaques from the brain.

How To Implement The Alzheimer’s Diet

The Alzheimer’s diet should be tailored to meet the unique needs of the individual in order to receive the most enhanced cognitive benefit. At the Amos Institute, clients receive an immersive and individualized nutrition plan that incorporates the major components of the Alzheimer’s diet, with specifications related to their personal drivers of cognitive decline, genetics, and biochemistry.

This is particularly important when considering the genetic variant ApoE4, the genetic variant most commonly associated with increased risk for Alzheimer’s disease. Individuals with this variant demonstrate what is known as decreased cerebral glucose utilization, meaning that their brains do not effectively utilize carbohydrates as a fuel source.

To bypass these impaired metabolic pathways, individuals with this genetic variant are encouraged to achieve a state of mild ketosis

Creating a ketogenic diet based largely on plant foods can be challenging, which is why seeking the help of functional medicine-trained dietitians is so critical for proper implementation. This is where partnering with a program and practitioners such as those from the Amos Institute is so beneficial to success in recovery.

Reversing The Symptoms Of Alzheimer’s Disease

Reversing the symptoms of Alzheimer’s disease and cognitive decline is incredibly difficult, but the research shows that it can be done. If you believe you are at risk of developing Alzheimer’s disease, start implementing the Alzheimer’s diet right away.

If you are already suffering from cognitive decline, seek the expertise and structure of a cognitive health program to begin optimizing your nutrition and lifestyle to reverse your cognitive decline. In the words of Dr. Dale Bredesen, if we all start to implement an Alzheimer’s diet and other lifestyle factors, “Alzheimer’s disease should be- and shall be- a rare disease.” 

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Writer Bio – Amylee Amos Dietician and Nutritionist

 

Amylee Amos MS, RDN, IFMCP founded the Amos Institute to specialize in the implementation of the Bredesen Protocol. She graduated with a Master of Science in Nutrition, Healthspan, & Longevity from the University of Southern California’s Leonard Davis School of Gerontology.

She has trained under Dr. Dale Bredesen and received certification in the Bredesen Protocol from MPI Cognition. She is one of the only dietitians in the United States who is certified by the Institute for Functional Medicine, a new high-level achievement for leading medical providers.

 

Magnesium Deficiency Symptoms And Treatment

symptoms of magnesium deficiency

Magnesium Deficiency Symptoms And Causes

Magnesium deficiency symptoms and treatment depend on the severity of the deficiency. We always talk about how minerals like Calcium and Iron are so important for our bodies. Magnesium, the 4th most common mineral in the body, is gaining a lot of attention these days. That’s because more and more people are ingesting less than the Lower Reference Nutrient Intake (LRNI) and hence are prone to Magnesium deficiency.  [Derbyshire] Magnesium deficiency symptoms could be treated by increasing the intake of magnesium by taking magnesium supplements, including Magnesium-rich foods and correcting dietary habits. This essential mineral is very demanding and you will agree with me as you read further. Let’s learn more about Magnesium deficiency symptoms, causes, and treatment.

What is Magnesium good for?

Magnesium is needed for some of the most basic processes such as energy production and synthesis of RNA and DNA. There are over 300 enzyme systems that require Magnesium for protein synthesis, muscle contraction, blood glucose control, nerve function and many more!

How much Magnesium do I need?

As per the British Nutrition Foundation, 2016, males who are 15 years old and above need 300 mg/day.  15- 18 yr old females need 300 mg/day, while those 19 years and above require 270 mg/day. 

The US FDA has set higher requirements (RDA) of magnesium. 

Magnesium deficiency:

The normal concentration of Magnesium in serum is 75–95 mmol/L. Research shows that serum levels of Magnesium less than 85 mmol/l indicate a Magnesium deficiency. 

Why does magnesium deficiency often go undetected?

Serum magnesium does not amount for the intracellular magnesium i.e. magnesium inside the cell, which in fact makes up for most of the magnesium in the body. This is the reason why magnesium deficiency goes undetected in most cases. [DiNicolantonio et al.]

What are the causes of Magnesium deficiency?

Many of us are deficient in this essential mineral as a result of chronic diseases and many other reasons listed below:

  1. Cooking and boiling vegetables leads to loss of magnesium content in food
  2. Reduced levels of magnesium in processed foods
  3. Meat, sugar, white flour provide less than 20% of the Magnesium required daily
  4. Alcohol, coffee, tea, soft drinks, salt, and sugar increase the excretion of Magnesium.
  5. Increased excretion of Mg is seen in case heavy menstruation, excessive sweating, increased stress
  6. Disease involving increased Mg excretion: Type 1 or Type 2 diabetes, prolonged vomiting/diarrhea, severe sunburns, hypoparathyroidism, gastrointestinal disorders such as gluten sensitivity, ulcers, and inflammatory bowel disease (IBD) 
  7. Other diseases: Cancer (increased demand for Mg), liver diseases such as cirrhosis, hemochromatosis (iron overload) etc. (leading to Vitamin  D deficiency and therefore reduced Mg absorption), viral, fungal or bacterial infectious agents that cause widespread tissue death, renal transplantation, etc (depleting Mg)  [S Johnson]
  8. Cigarette smoking reduced the plasma concentration
  9. Soil depletion of nutrients due to some fertilization methods and agricultural techniques
  10. Use of pesticides- some of the pesticides have the ability to bind minerals such as Magnesium thereby lowering its content in the soil and produce. Consider eating clean or eating organic
  11.  Aging- another cause for reduced absorption
  12. Medications such as diuretics, antacids, antibiotics, etc. diminish Mg absorption. [Schwalfenberg et al.]

Yes…it is surprising how so many factors influence magnesium levels and at least one of them is bound to go wonky at some point. No wonder magnesium deficiency is becoming so common these days.

Common Magnesium Deficiency Symptoms:

Clinical signs of magnesium deficiency may not be seen in most cases as it is in the latent stage. You may experience general weakness, tiredness, leg pain, irritability and so on.

Severe Magnesium Deficiency Symptoms:

  1. Neuromuscular- weakness, tremors, facial twitching, muscle spasm of the hand and forearm
  2. Central Nervous system- increased risk of depression, agitation, involuntary eye movements (nystagmus), seizures
  3. Cardiac- irregular heartbeat

Magnesium Deficiency Symptoms And Treatment In Relation To The Level Of Deficiency Of Magnesium In The Body

 

Benefits of Magnesium supplement:

The upper tolerable limit for Mg supplementation is 350 mg/day.

Research indicates that supplementing with magnesium can help alleviate some ailments and help improve general well-being as well. However, further research for some of the benefits is needed.

Reduces hypertension:

-Magnesium helps prevent the blood vessels from constricting which reduces blood pressure. [Jee et al., Zhang et al.]

Bone health:

-Suppresses bone turnover (which in very simple terms means bone is broken down and re-made) in post-menopausal women and young men and can thereby prevent osteoporosis [Aydin H et al., Dimai HP et al.]

Halves the risk of eclampsiain pregnant WOMEN [The Magpie Trial Collaborative Group]:

-Eclampsia –meaning convulsions in pregnant women with high blood pressure. This is again due to the ability of Magnesium to reduce blood pressure.

Magnesium isstrongly recommended for migraine-

-In this case, Magnesium citrate has been shown to be effective in migraine without aura. Whereas, Magnesium sulfate may be useful in migraine patients with aura. [Bigal ME et al.]

Reduces the risk of diabetes:

 -Magnesium helps improve glucose control and insulin levels. [Kim DJ et al., Hruby A et al.]

Used in Treating Depression and may help prevent depression [Derom ML et al.]

-Magnesium plays a vital role in brain health. In that, it controls the neurotransmitters which send signals throughout the body. For example, Magnesium is essential to produce Serotonin, the happy hormone.

Helps improve symptoms of insomnia:

– This is because Magnesium plays a key role in sleep regulation.[Abbasi B et al.]

Cancer:

– Magnesium supplementation reduced the risk of colorectal cancer. [Wark et al.]

Premenstrual symptoms:

-Magnesium helps decrease premenstrual symptoms. [Walker et al., Facchinetti et al.

Smoking:

-Magnesium helps reduce the number of cigarettes smoked. [Nechifor et al.]

Exercise:

-Few studies show Magnesium can actually help increase exercise capacity in athletes during periods of stress and increases oxygenation. [Golf SW et al.]

What is the best form of magnesium?

The answer to this question is debatable.  However, I will list some of the research that’s been done or is on-going. 

Magnesium citrate:

Studies show that Magnesium citrate (MgC) has higher bioavailability as compared to MgO. A review by Rylander et al. shows more than one study supporting this fact. I found this interesting article where Anna Bolton O’Byrne talks about the study they conducted on Magnesium citrate v/s Magnesium glycinate (MgG). Their results show that  MgC is better than MgG in terms of increasing magnesium concentration in blood serum and urine. MgC could help improve overall magnesium levels in the body. MgC is also beneficial in migraine without aura.[Bigal ME et al.]

Magnesium glycinate (also known as Magnesium bisglycinate)  and Magnesium taurinate:

There are rumors that Magnesium glycinate (MgG) is the most bio-available. However, upon researching, I found that it lacks enough evidence to prove it. There are a few case studies discussed in this paper by Eby GA et al.  which say that MgG and Magnesium taurinate (MgT) assist in recovering from depression. Interestingly, Glycine and Taurine are neurotransmitters which explain their beneficial effects on depression. Not only that, Magnesium is mostly deficient in depressed individuals. If you are stressed out, MgG may help you better as it contains Glycine which is known for its soothing effect. 

(By the way, MgG is the one I use. I take it in combination with pyridoxine and it works well for me. I have found it beneficial in reducing premenstrual symptoms such as bloating, pain and abdominal discomfort.)

Magnesium chloride:

Magnesium chloride (MgC) has greater bioavailability as compared to MgO. It is proved to be effective in the treatment of mild-to-moderate depression. [Tarleton et al.] But it has gastrointestinal (GI) side-effects such as bloating and diarrhea.

Magnesium sulfate:

This is also known as Epsom salt, which is used for a relaxing bath. Some papers talk about the intravenous use of Magnesium sulfate (MgS) in pregnancy blood pressure and eclampsia. In fact, the WHO recommends MgS for the prevention and treatment of eclampsia. There’s evidence for its use in migraine with aura. [Bigal ME et al.]

Magnesium threonate:

This form of Magnesium has been studied in patients with mild-to-moderate dementia. The patients showed improved cognitive abilities after 12 weeks of supplementation.

Magnesium oxide:

Magnesium oxide (MgO) has very low bioavailability and has GI side-effects such as diarrhea. However, it is occasionally used as a laxative.

How should I take a magnesium supplement?

In my case, taking 2 capsules at a time increases bowel movement. So, I take my magnesium supplement twice a day, one in the morning/afternoon and one at night. 

Note: Please consult a physician to decide upon the dosage you need since diseases and a host of other factors come into play when Magnesium is concerned.

What should you take with magnesium?

Magnesium goes well with:

  1. Magnesium with Pyridoxine (vitamin B6) showed a greater effect on people under severe stress. [Pouteau et al.
  2. Vitamin D: The sunshine vitamin is a must for the absorption of Magnesium. It is better to get yourself checked for vitaminD deficiency and correct it.

 

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Magnesium Rich Foods:

Hemp seeds, Pumpkin seeds, Flax seeds, Cacao, and Brazil nuts are super-rich in this mineral. Almonds, Spinach, Cashews, Peanuts, Cereals, Soy-milk and Edamame are some good sources of Magnesium.

Improve Magnesium Absorption:

    1. High calcium intake may decrease magnesium absorption. Ideally, avoid taking calcium-rich foods or supplements 2 hrs before and after Magnesium-rich food or supplements. 
    2. Cut down on or if possible avoid the consumption of Sodas, Alcohol, Tea, and Coffee
    3. Treat Vitamin D deficiency
    4. Consume raw vegetables and reduce consumption of processed foods
    5. Quit smoking.
    6. Try including “clean” or organic foods in your diet since they contain higher amounts of nutrients including Magnesium. [Crinnion WJ]

magnesium rich super foods infographic

Summary:

  • Magnesium is essential for basic processes such as energy production and for the proper functioning of 300 enzyme systems.
  • As per The British Nutrition Foundation, the requirement of magnesium is 300 mg/day, varying as per gender, age, nationality, and in case of deficiency.
  • The signs and symptoms of Magnesium deficiency are often unseen. They manifest depending on the severity of the deficiency. Some of the symptoms are facial twitches, neuromuscular weakness, tremors, seizures, irregular heartbeat, depression, etc.
  • Magnesium absorption and elimination are influenced by several factors including medications,  gastrointestinal and renal diseases, other nutrient deficiencies such as Vitamin D, stress, some agricultural practices, and cooking resulting in the foods’ Magnesium content.
  • Magnesium can aid in alleviating migraine, depression, hypertension/eclampsia in pregnancy, insomnia, premenstrual symptoms, and stress; reducing the risk of diabetes and cancer; improving exercise capacity and helping reduce the number of cigarettes smoked.
  • Among the many forms of Magnesium supplements, Magnesium citrate seems to be the most bio-available and safe. Magnesium glycinate is another great option if you are looking for relief from stress. 
  • Hemp seeds, Pumpkin seeds, Flax seeds, and Brazil nuts are super rich in magnesium. Almonds, Spinach, Cashews, and Peanuts are also good sources of magnesium.
  • Consider consulting a physician to decide upon the dosage since magnesium metabolism is affected by a ton of other factors. 
  • Magnesium goes well with Pyridoxine and vitamin D.

Some Simple Tips To Increase Magnesium Levels are:-

  1. Leave a gap of 2 hrs before and after Magnesium-rich foods 
  2. Treat Vitamin D deficiency
  3. Reduce the consumption of processed foods and have more raw veggies
  4. Try cutting down on sodas (soft drinks), alcohol, tea, and coffee
  5. Quit smoking
  6. Try including “clean” or organic foods in your diet

 

 

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